Lipidomics Standards Initiative (LSI)
LSI aims to create guidelines for the major lipidomic workflows in a community-wide effort.
The guidelines/standards include the various analytical steps in a lipidomics workflow, guiding how to:
- collect and store samples
- extract lipids
- execute the MS analysis
- perform data processing, including lipid identification, deconvolution, annotation,
quantification, and evaluation of quality control - how to report the data
The guidelines also cover the validation of analytical methods and the use of quality controls.
Standards are essential for a successful progress of lipidomics because they provide a common language for researchers within lipdomics and the interface to interlink to other disciplines. Therefore LSI closely interacts with the other interest groups within the International Lipidomics Society.
Moreover, LSI established collaborations with LIPID MAPS (https://www.lipidmaps.org/) and is in exchange with other standardization initiatives such as proteomics (PSI) and metabolomics (MSI) standards initiatives.
Please see more info about Lipidomic Standardization at: https://lipidomicsstandards.org/
Steering committee:
Michal Holčapek
Harald Köfeler
Justine Bertrand-Michel, France
Christer Ejsing, Denmark
Jeffrey McDonald, USA
Former steering committee members:
Maria Fedorova, Germany (until Aug. 2024)

Pitfalls in Lipid Mass Spectrometry of Mammalian Samples: A Brief Guide for Biologists
Oslo, Norway – [July 2nd 2024] – A collaborative team of leading scientists has published a crucial guide addressing the common pitfalls in lipid mass spectrometry
LSI Publication – Introducing the Lipidomics Minimal Reporting Checklist
LSI Guidelines Workshops at ELM 2020 and Lipidomics Forum
The Lipidomics Standards Initiative interest group of the ILS is offering two workshops at this year’s joint European Lipidomics Meeting and Lipidomics Forum. Please find